NIH Research Activities

Biomarkers and
Surrogate Endpoints

OVERVIEW

Slide 3

BIOMARKERS –
NIH RESEARCH INTERESTS

NIH INITIATIVES

NIH INITIATIVES (cont.)

Major Needs and Opportunities

FDAMA

DEFINITIONS

DEFINITIONS

DEFINITIONS

DEFINITIONS

Conceptual Model
Biomarkers and Surrogate Endpoints

Capturing the Proportion of Treatment Effect

APPROACHES TO CLASSIFY BIOMARKERS

Slide 16

Slide 17

Biomarker Discovery Approaches

Slide 19

DNA Arrays Technologies:
Characterizing Disease Markers and …

NIH Research Initiatives

Cancer Biomarkers
http://edrn.nci.nih.gov

Osteoarthritis Initiative
http://www.nih.gov/niams/news/oisg/index.htm

Biomarker Research Needs

Biomarker Research Needs

Closing Remarks