NIH Research Activities -
Biomarkers and Surrogate Endpoints

OVERVIEW

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BIOMARKERS –
NIH RESEARCH INTERESTS

NIH INITIATIVES

NIH INITIATIVES (cont.)

FDAMA

DEFINITIONS

DEFINITIONS

DEFINITIONS

DEFINITIONS

Conceptual Model
Biomarkers and Surrogate Endpoints

Capturing the Proportion of Treatment Effect

APPROACHES TO CLASSIFY BIOMARKERS

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BIOMARKER DISCOVERY APPROACHES

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NIH Research Initiatives

Cancer Biomarkers
http://edrn.nci.nih.gov

Osteoarthritis Initiative
http://www.nih.gov/niams/news/oisg/index.htm

RESEARCH NEEDS

RESEARCH NEEDS

CLOSING REMARKS